Publications

2020

Mulcahy E.Q., Rivera Colón R, Abounader R, HGF/MET Signaling in Malignant Brain Tumors, 2020; International Journal of Molecular Sciences. 21(20), 7546. 

2019

Ngulde SI, Sandabe UK, Abounader R, Dawson TK, Zhang Y, Iliya I, Hussaini IM, Ethanol Extract of Securidaca longipedunculata Induces Apoptosis in Brain Tumor (U87) Cells., 2019; BioMed research international. 2019() 9826590. PMID: 30931334 | PMCID: PMC6413385

Yang Y, Dodbele S, Park T, Glass R, Bhat K, Sulman EP, Zhang Y, Abounader R, MicroRNA-29a inhibits glioblastoma stem cells and tumor growth by regulating the PDGF pathway., 2019; Journal of neuro-oncology. 145(1) 23-34. PMID: 31482267

Jung J, Zhang Y, Celiku O, Zhang W, Song H, Williams BJ, Giles AJ, Rich JN, Abounader R, Gilbert MR, Park DM, Mitochondrial NIX Promotes Tumor Survival in the Hypoxic Niche of Glioblastoma., 2019; Cancer research. 79(20) 5218-5232. PMID: 31488423 | PMCID: PMC6801103

Cruickshanks N, Zhang Y, Hine S, Gibert M, Yuan F, Oxford M, Grello C, Pahuski M, Dube C, Guessous F, Wang B, Deveau C, Saoud K, Gallagher I, Wulfkuhle J, Schiff D, Phan S, Petricoin E, Abounader R, Discovery and Therapeutic Exploitation of Mechanisms of Resistance to MET Inhibitors in Glioblastoma., 2019; Clinical cancer research : an official journal of the American Association for Cancer Research. 25(2) 663-673. PMID: 30201763 | PMCID: PMC6335175

2018

Olmez I, Zhang Y, Manigat L, Benamar M, Brenneman B, Nakano I, Godlewski J, Bronisz A, Lee J, Abbas T, Abounader R, Purow B, Combined c-Met/Trk Inhibition Overcomes Resistance to CDK4/6 Inhibitors in Glioblastoma., 2018; Cancer research. 78(15) 4360-4369. PMID: 29844123 | PMCID: PMC6072607

Zhang Y, Dube C, Gibert M, Cruickshanks N, Wang B, Coughlan M, Yang Y, Setiady I, Deveau C, Saoud K, Grello C, Oxford M, Yuan F, Abounader R, The p53 Pathway in Glioblastoma., 2018; Cancers. 10(9) . PMID: 30200436 | PMCID: PMC6162501

Zhang Y, Kim J, Mueller AC, Dey B, Yang Y, Lee DH, Hachmann J, Finderle S, Park DM, Christensen J, Schiff D, Purow B, Dutta A, Abounader R, Correction to: Multiple receptor tyrosine kinases converge on microRNA-134 to control KRAS, STAT5B, and glioblastoma., 2018; Cell death and differentiation. 26(1) 197. PMID: 29899381 | PMCID: PMC6294759

Abounader R, A new practical and versatile mouse model of proneural glioblastoma., 2018; Neuro-oncology. 20(3) 299-301. PMID: 29432618 | PMCID: PMC5817963

Melhuish TA, Kowalczyk I, Manukyan A, Zhang Y, Shah A, Abounader R, Wotton D, Myt1 and Myt1l transcription factors limit proliferation in GBM cells by repressing YAP1 expression., 2018; Biochimica et biophysica acta. Gene regulatory mechanisms. 1861(11) 983-995. PMID: 30312684 | PMCID: PMC6203443

Gonzalez PP, Kim J, Galvao RP, Cruickshanks N, Abounader R, Zong H, p53 and NF 1 loss plays distinct but complementary roles in glioma initiation and progression., 2018; Glia. 66(5) 999-1015. PMID: 29392777

2017

Zhang Y, Cruickshanks N, Yuan F, Wang B, Pahuski M, Wulfkuhle J, Gallagher I, Koeppel AF, Hatef S, Papanicolas C, Lee J, Bar EE, Schiff D, Turner SD, Petricoin EF, Gray LS, Abounader R, Targetable T-type Calcium Channels Drive Glioblastoma., 2017; Cancer research. 77(13) 3479-3490. PMID: 28512247 | PMCID: PMC5505315

Cruickshanks N, Zhang Y, Yuan F, Pahuski M, Gibert M, Abounader R, Role and Therapeutic Targeting of the HGF/MET Pathway in Glioblastoma., 2017; Cancers. 9(7) . PMID: 28696366 | PMCID: PMC5532623

Olmez I, Brenneman B, Xiao A, Serbulea V, Benamar M, Zhang Y, Manigat L, Abbas T, Lee J, Nakano I, Godlewski J, Bronisz A, Abounader R, Leitinger N, Purow B, Combined CDK4/6 and mTOR Inhibition Is Synergistic against Glioblastoma via Multiple Mechanisms., 2017; Clinical cancer research : an official journal of the American Association for Cancer Research. 23(22) 6958-6968. PMID: 28814434 | PMCID: PMC5690820

Olmez I, Love S, Xiao A, Manigat L, Randolph P, McKenna BD, Neal BP, Boroda S, Li M, Brenneman B, Abounader R, Floyd D, Lee J, Nakano I, Godlewski J, Bronisz A, Sulman EP, Mayo M, Gioeli D, Weber M, Harris TE, Purow B, Targeting the mesenchymal subtype in glioblastoma and other cancers via inhibition of diacylglycerol kinase alpha., 2017; Neuro-oncology. () . PMID: 29048560 | PMCID: PMC5777487

2016

Vega RA, Zhang Y, Curley C, Price RL, Abounader R, 370 Magnetic Resonance-Guided Focused Ultrasound Delivery of Polymeric Brain-Penetrating Nanoparticle MicroRNA Conjugates in Glioblastoma., 2016; Neurosurgery. 63() 210. PMID: 27399567

Reon BJ, Anaya J, Zhang Y, Mandell J, Purow B, Abounader R, Dutta A, Expression of lncRNAs in Low-Grade Gliomas and Glioblastoma Multiforme: An In Silico Analysis., 2016; PLoS medicine. 13(12) e1002192. PMID: 27923049 | PMCID: PMC5140055

2015

Lee DH, Zhang Y, Kassam AB, Park MJ, Gardner P, Prevedello D, Henry S, Horbinski C, Beumer JH, Tawbi H, Williams BJ, Shaffrey ME, Egorin MJ, Abounader R, Park DM, Combined PDGFR and HDAC Inhibition Overcomes PTEN Disruption in Chordoma., 2015; PloS one. 10(8) e0134426. PMID: 26247786 | PMCID: PMC4527706

2014

Floyd DH, Zhang Y, Dey BK, Kefas B, Breit H, Marks K, Dutta A, Herold-Mende C, Synowitz M, Glass R, Abounader R, Purow BW, Novel anti-apoptotic microRNAs 582-5p and 363 promote human glioblastoma stem cell survival via direct inhibition of caspase 3, caspase 9, and Bim., 2014; PloS one. 9(5) e96239. PMID: 24805821 | PMCID: PMC4013090

Kim J, Zhang Y, Skalski M, Hayes J, Kefas B, Schiff D, Purow B, Parsons S, Lawler SE, Abounader R, microRNA-148a is a prognostic oncomiR that targets MIG6 and BIM to regulate EGFR and apoptosis in glioblastoma., 2014; Cancer research. () . PMID: 24425048 | PMCID: PMC3947487

Zhang Y, Kim J, Mueller AC, Dey B, Yang Y, Lee DH, Hachmann J, Finderle S, Park DM, Christensen J, Schiff D, Purow B, Dutta A, Abounader R, Multiple receptor tyrosine kinases converge on microRNA-134 to control KRAS, STAT5B, and glioblastoma., 2014; Cell death and differentiation. 21(5) 720-34. PMID: 24440911 | PMCID: PMC3978301

Feng C, Zhang Y, Yin J, Li J, Abounader R, Zuo Z, Regulatory factor X1 is a new tumor suppressive transcription factor that acts via direct downregulation of CD44 in glioblastoma., 2014; Neuro-oncology. 16(8) 1078-85. PMID: 24526308 | PMCID: PMC4096175

Zhang Y, Schiff D, Park D, Abounader R, MicroRNA-608 and microRNA-34a regulate chordoma malignancy by targeting EGFR, Bcl-xL and MET., 2014; PloS one. 9(3) e91546. PMID: 24621885 | PMCID: PMC3951453

Negishi M, Wongpalee SP, Sarkar S, Park J, Lee KY, Shibata Y, Reon BJ, Abounader R, Suzuki Y, Sugano S, Dutta A, A New lncRNA, APTR, Associates with and Represses the CDKN1A/p21 Promoter by Recruiting Polycomb Proteins., 2014; PloS one. 9(4) e95216. PMID: 24748121 | PMCID: PMC3991591

Awad AJ, Burns TC, Zhang Y, Abounader R, Targeting MET for glioma therapy., 2014; Neurosurgical focus. 37(6) E10. PMID: 25434379

2013

Guessous F, Alvarado-Velez M, Marcinkiewicz L, Zhang Y, Kim J, Heister S, Kefas B, Godlewski J, Schiff D, Purow B, Abounader R, Oncogenic effects of miR-10b in glioblastoma stem cells., 2013; Journal of neuro-oncology. 112(2) 153-63. PMID: 23307328 | PMCID: PMC3609924

Dominguez CL, Floyd DH, Xiao A, Mullins GR, Kefas BA, Xin W, Yacur MN, Abounader R, Lee JK, Wilson GM, Harris TE, Purow BW, Diacylglycerol kinase α is a critical signaling node and novel therapeutic target in glioblastoma and other cancers., 2013; Cancer discovery. 3(7) 782-97. PMID: 23558954 | PMCID: PMC3710531

Kofman AV, Letson C, Dupart E, Bao Y, Newcomb WW, Schiff D, Brown J, Abounader R, The p53-microRNA-34a axis regulates cellular entry receptors for tumor-associated human herpes viruses., 2013; Medical hypotheses. 81(1) 62-7. PMID: 23643704 | PMCID: PMC3676726

Huang X, Zhang Y, Tang Y, Butler N, Kim J, Guessous F, Schiff D, Mandell J, Abounader R, A novel PTEN/mutant p53/c-Myc/Bcl-XL axis mediates context-dependent oncogenic effects of PTEN with implications for cancer prognosis and therapy., 2013; Neoplasia (New York, N.Y.). 15(8) 952-65. PMID: 23908595 | PMCID: PMC3730046

Kofman AV, Kim J, Park SY, Dupart E, Letson C, Bao Y, Ding K, Chen Q, Schiff D, Larner J, Abounader R, microRNA-34a promotes DNA damage and mitotic catastrophe., 2013; Cell cycle (Georgetown, Tex.). 12(22) 3500-11. PMID: 24091633 | PMCID: PMC3906336

Kefas B, Floyd DH, Comeau L, Frisbee A, Dominguez C, Dipierro CG, Guessous F, Abounader R, Purow B, A miR-297/hypoxia/DGK-α axis regulating glioblastoma survival., 2013; Neuro-oncology. 15(12) 1652-63. PMID: 24158111 | PMCID: PMC3829588

2011

Kofman A, Marcinkiewicz L, Dupart E, Lyshchev A, Martynov B, Ryndin A, Kotelevskaya E, Brown J, Schiff D, Abounader R, The roles of viruses in brain tumor initiation and oncomodulation., 2011; Journal of neuro-oncology. 105(3) 451-66. PMID: 21720806 | PMCID: PMC3278219

Kofman AV, Abounader R, When tumor cells make blood vessels: implications for glioblastoma therapy., 2011; Future oncology (London, England). 7(7) 841-3. PMID: 21732755 | PMCID: PMC3278210

Catania A, Maira F, Skarmoutsou E, D'Amico F, Abounader R, Mazzarino MC, Insight into the role of microRNAs in brain tumors (review)., 2011; International journal of oncology. 40(3) 605-24. PMID: 22179098

Guessous F, Yang Y, Johnson E, Marcinkiewicz L, Smith M, Zhang Y, Kofman A, Schiff D, Christensen J, Abounader R, Cooperation between c-Met and focal adhesion kinase family members in medulloblastoma and implications for therapy., 2011; Molecular cancer therapeutics. 11(2) 288-97. PMID: 22188814 | PMCID: PMC3277676

Zhang Y, Dutta A, Abounader R, The role of microRNAs in glioma initiation and progression., 2011; Frontiers in bioscience : a journal and virtual library. 17() 700-12. PMID: 22201769 | PMCID: PMC3278211

2010

Guessous F, Zhang Y, Kofman A, Catania A, Li Y, Schiff D, Purow B, Abounader R, microRNA-34a is tumor suppressive in brain tumors and glioma stem cells., 2010; Cell cycle (Georgetown, Tex.). 9(6) 1031-6. PMID: 20190569 | PMCID: PMC3278213

Zhang Y, Guessous F, Kofman A, Schiff D, Abounader R, XL-184, a MET, VEGFR-2 and RET kinase inhibitor for the treatment of thyroid cancer, glioblastoma multiforme and NSCLC., 2010; IDrugs : the investigational drugs journal. 13(2) 112-21. PMID: 20127563 | PMCID: PMC3268517

2009

Guessous F, Zhang Y, diPierro C, Marcinkiewicz L, Sarkaria J, Schiff D, Buchanan S, Abounader R, An orally bioavailable c-Met kinase inhibitor potently inhibits brain tumor malignancy and growth., 2009; Anti-cancer agents in medicinal chemistry. 10(1) 28-35. PMID: 20015006 | PMCID: PMC3278215

Li Y, Guessous F, DiPierro C, Zhang Y, Mudrick T, Fuller L, Johnson E, Marcinkiewicz L, Engelhardt M, Kefas B, Schiff D, Kim J, Abounader R, Interactions between PTEN and the c-Met pathway in glioblastoma and implications for therapy., 2009; Molecular cancer therapeutics. 8(2) 376-85. PMID: 19190120

Abounader R, Interactions between PTEN and receptor tyrosine kinase pathways and their implications for glioma therapy., 2009; Expert review of anticancer therapy. 9(2) 235-45. PMID: 19192961 | PMCID: PMC2678856

Li Y, Guessous F, Zhang Y, Dipierro C, Kefas B, Johnson E, Marcinkiewicz L, Jiang J, Yang Y, Schmittgen TD, Lopes B, Schiff D, Purow B, Abounader R, MicroRNA-34a inhibits glioblastoma growth by targeting multiple oncogenes., 2009; Cancer research. 69(19) 7569-76. PMID: 19773441 | PMCID: PMC2756313

Kefas B, Comeau L, Floyd DH, Seleverstov O, Godlewski J, Schmittgen T, Jiang J, diPierro CG, Li Y, Chiocca EA, Lee J, Fine H, Abounader R, Lawler S, Purow B, The neuronal microRNA miR-326 acts in a feedback loop with notch and has therapeutic potential against brain tumors., 2009; The Journal of neuroscience : the official journal of the Society for Neuroscience. 29(48) 15161-8. PMID: 19955368 | PMCID: PMC2823067

Guessous F, Zhang Y, diPierro C, Marcinkiewicz L, Sarkaria J, Schiff D, Buchanan S, Abounader R, An orally bioavailable c-Met kinase inhibitor potently inhibits brain tumor malignancy and growth., 2009; Anti-cancer agents in medicinal chemistry. 10(1) 28-35. PMID: 20015006 | PMCID: PMC3278215

2008

Kefas B, Godlewski J, Comeau L, Li Y, Abounader R, Hawkinson M, Lee J, Fine H, Chiocca EA, Lawler S, Purow B, microRNA-7 inhibits the epidermal growth factor receptor and the Akt pathway and is down-regulated in glioblastoma., 2008; Cancer research. 68(10) 3566-72. PMID: 18483236

Li Y, Guessous F, Kwon S, Kumar M, Ibidapo O, Fuller L, Johnson E, Lal B, Hussaini I, Bao Y, Laterra J, Schiff D, Abounader R, PTEN has tumor-promoting properties in the setting of gain-of-function p53 mutations., 2008; Cancer research. 68(6) 1723-31. PMID: 18339852 | PMCID: PMC3813002

Reznik TE, Sang Y, Ma Y, Abounader R, Rosen EM, Xia S, Laterra J, Transcription-dependent epidermal growth factor receptor activation by hepatocyte growth factor., 2008; Molecular cancer research : MCR. 6(1) 139-50. PMID: 18234969 | PMCID: PMC2839502

Guessous F, Li Y, Abounader R, Signaling pathways in medulloblastoma., 2008; Journal of cellular physiology. 217(3) 577-83. PMID: 18651559

Select publications from 2007 and earlier

Li Y, Guessous F, Johnson EB, Eberhart CG, Li XN, Shu Q, Fan S, Lal B, Laterra J, Schiff D, Abounader R, Functional and molecular interactions between the HGF/c-Met pathway and c-Myc in large-cell medulloblastoma., 2007; Laboratory investigation; a journal of technical methods and pathology. 88(2) 98-111. PMID: 18059365

Xu J, Gao M, Fan S, Meng Q, Goldberg ID, Abounader R, Ressom H, Laterra JJ, Rosen EM, Effect of Akt inhibition on scatter factor-regulated gene expression in DU-145 human prostate cancer cells., 2006; Oncogene. 26(20) 2925-38. PMID: 17099727

Abounader R, Laterra J, Scatter factor/hepatocyte growth factor in brain tumor growth and angiogenesis., 2005; Neuro-oncology. 7(4) 436-51. PMID: 16212809 | PMCID: PMC1871724

Li Y, Lal B, Kwon S, Fan X, Saldanha U, Reznik TE, Kuchner EB, Eberhart C, Laterra J, Abounader R, The scatter factor/hepatocyte growth factor: c-met pathway in human embryonal central nervous system tumor malignancy., 2005; Cancer research. 65(20) 9355-62. PMID: 16230398

Lal B, Xia S, Abounader R, Laterra J, Targeting the c-Met pathway potentiates glioblastoma responses to gamma-radiation., 2005; Clinical cancer research : an official journal of the American Association for Cancer Research. 11(12) 4479-86. PMID: 15958633

Beckner ME, Gobbel GT, Abounader R, Burovic F, Agostino NR, Laterra J, Pollack IF, Glycolytic glioma cells with active glycogen synthase are sensitive to PTEN and inhibitors of PI3K and gluconeogenesis., 2005; Laboratory investigation; a journal of technical methods and pathology. 85(12) 1457-70. PMID: 16170333

Abounader R, Montgomery R, Dietz H, Laterra J, Design and expression of chimeric U1/ribozyme transgenes., 2004; Methods in molecular biology (Clifton, N.J.). 252() 209-19. PMID: 15017051

Abounader R, Reznik T, Colantuoni C, Martinez-Murillo F, Rosen EM, Laterra J, Regulation of c-Met-dependent gene expression by PTEN., 2004; Oncogene. 23(57) 9173-82. PMID: 15516982

Su W, Gutmann DH, Perry A, Abounader R, Laterra J, Sherman LS, CD44-independent hepatocyte growth factor/c-Met autocrine loop promotes malignant peripheral nerve sheath tumor cell invasion in vitro., 2004; Glia. 45(3) 297-306. PMID: 14730703

Liang H, O'Reilly S, Liu Y, Abounader R, Laterra J, Maher VM, McCormick JJ, Sp1 regulates expression of MET, and ribozyme-induced down-regulation of MET in fibrosarcoma-derived human cells reduces or eliminates their tumorigenicity., 2004; International journal of oncology. 24(5) 1057-67. PMID: 15067326

Herynk MH, Stoeltzing O, Reinmuth N, Parikh NU, Abounader R, Laterra J, Radinsky R, Ellis LM, Gallick GE, Down-regulation of c-Met inhibits growth in the liver of human colorectal carcinoma cells., 2003; Cancer research. 63(11) 2990-6. PMID: 12782608

Jiang WG, Grimshaw D, Martin TA, Davies G, Parr C, Watkins G, Lane J, Abounader R, Laterra J, Mansel RE, Reduction of stromal fibroblast-induced mammary tumor growth, by retroviral ribozyme transgenes to hepatocyte growth factor/scatter factor and its receptor, c-MET., 2003; Clinical cancer research : an official journal of the American Association for Cancer Research. 9(11) 4274-81. PMID: 14519655

Moreno MJ, Abounader R, Hébert E, Doods H, Hamel E, Efficacy of the non-peptide CGRP receptor antagonist BIBN4096BS in blocking CGRP-induced dilations in human and bovine cerebral arteries: potential implications in acute migraine treatment., 2002; Neuropharmacology. 42(4) 568-76. PMID: 11955527

Bannon DI, Abounader R, Lees PS, Bressler JP, Effect of DMT1 knockdown on iron, cadmium, and lead uptake in Caco-2 cells., 2002; American journal of physiology. Cell physiology. 284(1) C44-50. PMID: 12388109

Abounader R, Ranganathan S, Kim BY, Nichols C, Laterra J, Signaling pathways in the induction of c-met receptor expression by its ligand scatter factor/hepatocyte growth factor in human glioblastoma., 2001; Journal of neurochemistry. 76(5) 1497-508. PMID: 11238734

Jiang WG, Grimshaw D, Lane J, Martin TA, Abounader R, Laterra J, Mansel RE, Abounder R, A hammerhead ribozyme suppresses expression of hepatocyte growth factor/scatter factor receptor c-MET and reduces migration and invasiveness of breast cancer cells., 2001; Clinical cancer research : an official journal of the American Association for Cancer Research. 7(8) 2555-62. PMID: 11489839

Abounader R, Lal B, Luddy C, Koe G, Davidson B, Rosen EM, Laterra J, In vivo targeting of SF/HGF and c-met expression via U1snRNA/ribozymes inhibits glioma growth and angiogenesis and promotes apoptosis., 2001; FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 16(1) 108-10. PMID: 11729097

Dumont Y, Cadieux A, Doods H, Pheng LH, Abounader R, Hamel E, Jacques D, Regoli D, Quirion R, BIIE0246, a potent and highly selective non-peptide neuropeptide Y Y(2) receptor antagonist., 2000; British journal of pharmacology. 129(6) 1075-88. PMID: 10725255 | PMCID: PMC1571943

Guerin C, Luddy C, Abounader R, Lal B, Laterra J, Glioma inhibition by HGF/NK2, an antagonist of scatter factor/hepatocyte growth factor., 2000; Biochemical and biophysical research communications. 273(1) 287-93. PMID: 10873600

Bowers DC, Fan S, Walter KA, Abounader R, Williams JA, Rosen EM, Laterra J, Scatter factor/hepatocyte growth factor protects against cytotoxic death in human glioblastoma via phosphatidylinositol 3-kinase- and AKT-dependent pathways., 2000; Cancer research. 60(15) 4277-83. PMID: 10945642

Abounader R, Elhusseiny A, Cohen Z, Olivier A, Stanimirovic D, Quirion R, Hamel E, Expression of neuropeptide Y receptors mRNA and protein in human brain vessels and cerebromicrovascular cells in culture., 1999; Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 19(2) 155-63. PMID: 10027771

Book AA, Ranganathan S, Abounader R, Rosen E, Laterra J, Scatter factor/hepatocyte growth factor gene transfer increases rat blood-glioma barrier permeability., 1999; Brain research. 833(2) 173-80. PMID: 10375692

Abounader R, Ranganathan S, Lal B, Fielding K, Book A, Dietz H, Burger P, Laterra J, Reversion of human glioblastoma malignancy by U1 small nuclear RNA/ribozyme targeting of scatter factor/hepatocyte growth factor and c-met expression., 1999; Journal of the National Cancer Institute. 91(18) 1548-56. PMID: 10491431

Abounader R, Hamel E, Associations between neuropeptide Y nerve terminals and intraparenchymal microvessels in rat and human cerebral cortex., 1997; The Journal of comparative neurology. 388(3) 444-53. PMID: 9368852

Vogel J, Abounader R, Schröck H, Zeller K, Duelli R, Kuschinsky W, Parallel changes of blood flow and heterogeneity of capillary plasma perfusion in rat brains during hypocapnia., 1996; The American journal of physiology. 270(4) H1441-5. PMID: 8967387

Abounader R, Vogel J, Kuschinsky W, Patterns of capillary plasma perfusion in brains in conscious rats during normocapnia and hypercapnia., 1995; Circulation research. 76(1) 120-6. PMID: 8001269

Abounader R, Villemure JG, Hamel E, Characterization of neuropeptide Y (NPY) receptors in human cerebral arteries with selective agonists and the new Y1 antagonist BIBP 3226., 1995; British journal of pharmacology. 116(4) 2245-50. PMID: 8564255 | PMCID: PMC1908978

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